Proportional constrained longitudinal data analysis models for clinical trials in sporadic Alzheimer's disease
Alzheimer s & Dementia Translational Research & Clinical Interventions2022Vol. 8(1), pp. e12286–e12286
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Guoqiao Wang, Lei Liu, Yan Li, Andrew J. Aschenbrenner, Randall J. Bateman, Paul Delmar, Lon S. Schneider, Richard Kennedy, Gary Cutter, Chengjie Xiong
Abstract
The PcLDA framework offers a variety of possibilities to model longitudinal data such as proportional MMRM (pMMRM) and two-part pMMRM which can model heterogeneous cohorts more efficiently and model co-primary endpoints simultaneously.
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