Bridging the rodent to human translational gap: Marmosets as model systems for the study of Alzheimer's disease
Alzheimer s & Dementia Translational Research & Clinical Interventions2023Vol. 9(3), pp. e12417–e12417
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Stacey J. Sukoff Rizzo, Gregg E. Homanics, David J. Schaeffer, Lauren K Hayrynen Schaeffer, Jung Eun Park, Julia Oluoch, Tingting Zhang, Annat Haber, Nicholas T. Seyfried, Benedict Paten, Anna Greenwood, Takeshi Murai, Sang Ho Choi, Hasi Huhe, Julia Kofler, Peter L. Strick, Gregory W. Carter, Afonso C. Silva
Abstract
By establishing marmoset models of AD, we will be able to investigate primate-specific cellular and molecular root causes that underlie the pathogenesis and progression of AD, overcome limitations of other model organisms, and support future translational studies to accelerate the pace of bringing therapies to patients.
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