Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community‐based cohort: an HABS‐HD study
Alzheimer s & Dementia Translational Research & Clinical Interventions2025Vol. 11(1), pp. e70045–e70045
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Melissa Petersen, Fan Zhang, James Hall, Courtney Brock, Robert A. Rissman, Tori Como, David Julovich, Mark Mapstone, Beau M. Ances, Karin L. Meeker, Raymond F. Palmer, Robert C. Barber, David Mason, Leigh Johnson, Kristine Yaffe, Arthur W. Toga, Annie Cohen, Sid E. O’Bryant, for the HABS‐HD Study Team
Abstract
Differences in AT(N) plasma biomarkers were found in a diverse community cohort.While plasma Aβ42/40 was associated with PET amyloid positivity among non-Hispanic white participants, this did not apply to non-Hispanic Black or Hispanic participants.Medical comorbidity of diabetes and chronic kidney disease was related to increased plasma AT(N) biomarkers among the ethnically diverse segment of the cohort.Plasma AT(N) biomarkers were more so related to a diagnosis of dementia for non-Hispanic white as compared to Hispanic or non-Hispanic Black participants.Across racial/ethnic groups, the plasma biomarkers of neurodegeneration (NfL) and ptau181 were related to a diagnosis of dementia.
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