Can Desmoplastic Stromal Reaction Guide the Extent of Lymph Node Surgery in Sporadic Medullary Thyroid Carcinoma?
World Journal of Surgery2026Vol. 50(3), pp. 650–659
Tuğba Matlim Özel, Husnu Aydin, Sezer Akbulut, Ahmet Çelik, Gorkem Yildiz, Gokce Aylaz, Müslüm Şahin, DENİZ GÜZEY, Huseyin Karatay, Nuri Alper Sahbaz, Safa Toprak, Orhan Ağcaoğlu, Ahmet Cem Dural, Serkan Volkan SARI
Abstract
DSR negativity reliably identifies an indolent subgroup with negligible metastatic risk, whereas increasing desmoplasia stratifies patients into higher-risk categories. The incorporation of DSR alongside established biomarkers such as Ctn may refine surgical decision-making and may help tailor the extent of LN dissection in sporadic MTC.