Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+
Bioscience Reports1984Vol. 4(9), pp. 797–805
Citations Over TimeTop 10% of 1984 papers
Abstract
Haemolysis by Sendai virus, alpha-toxin, and activated complement is inhibited by high concentrations of divalent cations. In Daudi cells, sublytic amounts of these agents induce the following changes: collapse of surface membrane potential, uptake of Na+ and loss of K+ from cells, and leakage of phosphorylated metabolites from cells. The changes induced by Sendai virus and complement are sensitive to physiological concentrations of extracellular Ca2+. It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain pore-forming agents on susceptible cells.
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