The fumarate reductase system as a site of anthelmintic attack in Ascaris suum
Bioscience Reports1984Vol. 4(10), pp. 879–883
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Abstract
Various benzimidazole compounds have been shown to be highly effective as inhibitors (up to 50% reduction of activity) in vitro of the helminth-specific enzyme, fumarate reductase, of Ascaris suum. Anthelmintically active and inactive benzimidazoles were similarly effective as inhibitors of enzyme activity. Albendazole-induced inhibition of fumarate reductase was not observed when the enzyme was preincubated with NADH.
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