Production of brefeldin-A
Journal of Industrial Microbiology & Biotechnology1995Vol. 15(1), pp. 5–9
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T. G. McCloud, Mark P. Burns, Fathy D. Majadly, Gary M. Muschik, Dorothea Miller, Kate Poole, John Roach, John T. Ross, William B. Lebherz
Abstract
Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.
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