Frequency of hereditary nonpolyposis colorectal cancer

Citations Over TimeTop 10% of 1995 papers

Abstract

Three (0.7 percent) cases of verified and seven (1.7 percent) cases of suspected HNPCC were identified, following the evaluation of all families with features indicative of susceptibility to cancer. The proportion of identifiable risk factors of CRC was 5.8-7.5 percent (HNPCC, 0.7-2.4 percent; previous CRC, 3.4 percent; ulcerative colitis, 1.0 percent; familial adenomatous polyposis coli, 0.7 percent). CONCLUSION. This prospective multicenter study revealed that the frequency of hereditary colorectal cancer is lower than in some previous studies, when diagnosis is based on extensive pedigree analysis. This result with recent findings of common ancestral founding mutation in Finnish HNPCC families indicates that there may be geographic differences in the occurrence of HNPCC. However, this does not change the fact that identification of HNPCC--perhaps one of the most common inherited diseases identified in humans--has become a question of vital importance now when diagnosis of the syndrome and large-scale screening of gene carriers using specific tests are on the horizon.

Related Papers

• → Controversies in the surgery of patients with familial adenomatous polyposis and Lynch syndrome(2016)13 cited
• → Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis(2016)12 cited
• → Mutational Screening of the APC Gene in Chilean Families with Familial Adenomatous Polyposis: Nine Novel Truncating Mutations(2007)13 cited
• → Mutation analysis of the adenomatous polyposis coli (APC) gene in Danish patients with familial adenomatous polyposis (FAP)(2004)12 cited
• → Overlapping phenotypes with AFAP and FAP in patients with Lynch syndrome gene mutations.(2014)