Glyceryl trinitrate for chronic anal fissure—Healing or headache?
Diseases of the Colon & Rectum2000Vol. 43(2), pp. 174–179
Citations Over TimeTop 1% of 2000 papers
Donato F. Altomare, Marcella Rinaldi, Giovanni Milito, Francesco Arcanà, Fernando Spinelli, Nicola Nardelli, Donato Scardigno, Antonio Pulvirenti-D'Urso, Corrado Bottini, Mario Pescatori, Roberta Lovreglio
Abstract
This trial fails to demonstrate any superiority of topical 0.2 percent glyceryl trinitrate treatment vs. a placebo, although the effects of glyceryl trinitrate on anodermal blood flow and sphincter pressure are confirmed. This finding, together with the high incidence of side-effects, should discourage the use of this treatment as a substitute for surgery in chronic anal fissure.
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