Effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat‐liver microsomes
Citations Over TimeTop 18% of 1984 papers
Abstract
Four groups of rats were fed diets containing 15% (w/w) high-oleic safflower oil (SFO, rich in cis-18:1 acids), a mixture of 80% partially hydrogenated soybean oil plus 20% corn oil (H + CO, rich in trans-18:1 acids), lard (L, rich in saturated fatty acids) and corn oil (Co, rich in 18:2 omega 6). Fatty acid composition of liver microsomes and activities of the delta 5, delta 6 and delta 9 desaturases were determined. Microsomal delta 6 desaturase activity and arachidonic acid were lower in the H + CO group compared with SFO of L. No difference was found in the delta 5 or delta 6 desaturase activity of CO and SFO groups. Thus, the oleic-acid level of the SFO diet had no effect on the metabolism of 18:2 omega 6. Fluorescent polarization studies, using trans-parinaric acid as a probe, showed no differences between the physical states of phospholipid vesicles made from lipids isolated from each group. We concluded that the trans-18:1 acids in partially hydrogenated soybean oil have a more inhibitory effect than saturated acids on EFA metabolism, even in the presence of adequate amounts of essential fatty acid.
Related Papers
- Arachidonic acid : dietary sources & general functions(2013)
- → Nonconversion of 5,11,14‐eicosatrienoic into arachidonic acid by rats(1970)13 cited
- 식이 지방산이 흰쥐 뇌조직 Subcellular Fractions내 Oleic Acid(ω9) 조성에 미치는 영향(2004)
- 논문 : 재배환경에 따른 광안콩 Oleic Acid 함량의 안정성(2012)
- → Effects of Dietary Fatty Acid Composition on Level of Oleic Acid (ω9) in Brain Subcellular Fractions of Rats(2004)