Distribution and metabolism of hexadecylphosphocholine in mice
Lipids1987Vol. 22(11), pp. 925–926
Citations Over TimeTop 24% of 1987 papers
A. Breiser, D. ‐J. Kim, E. A. M. Fleer, W. Damenz, A. Drube, M. Berger, Georg Nagel, H. Eibl, Clemens Unger
Abstract
Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He-PC) has been studied in mice. It is demonstrated that He-PC is well-absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2-diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He-PC breakdown.
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