Resolution ofvic‐dihydroxy acid diastereomers to four enantiomers by high‐performance liquid chromatography
Journal of the American Oil Chemists Society1994Vol. 71(5), pp. 547–548
Abstract
Abstract A chromatographic method is described for resolution of 9,10‐ vic ‐dihydroxyoctadecanoic acid. The threo and erythro isomers are both resolved into two enantiomers as di‐3,5‐dinitrophenylurethane derivatives by chiral‐phase highperformance liquid chromatography on ( S )‐proline, ( R )‐1‐(α‐naphthyl) ethylamine stationary phase. Simultaneous separation of the threo and erythro dihydroxy acid mixtures to the four enantiomers is possible by this method.
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