α-Secretase ADAM10 as Well as αAPPs Is Reduced in Platelets and CSF of Alzheimer Disease Patients
Molecular Medicine2002Vol. 8(2), pp. 67–74
Citations Over TimeTop 10% of 2002 papers
Francesca Colciaghi, Barbara Borroni, Lucia Pastorino, Elena Marcello, Martina Zimmermann, Flaminio Cattabeni, Alessandro Padovani, Mónica Di Luca
Abstract
ADAM10 is expressed in platelets. A reduced level of ADAM10 is observed in platelets obtained from AD patients compared to age-matched controls. Further, in the same pool of AD patients, a qualitatively and quantitatively similar decrease in alpha APPs is present both in thrombin-activated platelets and CSF, thus suggesting that alterations of APP processing might occur both in the neuronal compartment and peripheral cells.
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