Anx7 Is Required for Nutritional Control of Gene Expression in Mouse Pancreatic Islets of Langerhans
Molecular Medicine2002Vol. 8(12), pp. 781–797
Citations Over TimeTop 14% of 2002 papers
Abstract
We conclude that reduced gene dosage in the Anx7(+/-) islet, with concomitant loss of ITPR3 expression and consequent defects in Ca(2+) signaling, may substantially contribute to the mechanism of the loss of genomic discrimination, in vivo, between the fed and fasted states. We believe that the requirement for complete Anx7 gene dosage and IPTR3 expression in islets of Langerhans will prove to be of fundamental importance for understanding the mechanism of nutritional sensing in health and disease.
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