Structural Basis of Bloom Syndrome (BS) Causing Mutations in the BLM Helicase Domain
Molecular Medicine2000Vol. 6(3), pp. 155–164
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Abstract
The three-dimensional structure of the BLM helicase domain was modeled and applied to interpret BS-causing mutations. The mutation I841T is likely to weaken DNA binding, while the mutations C891R, C901Y, and Q672R presumably disturb the ATP binding. In addition, other critical positions are discussed.
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