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White Matter Microstructure Alterations in Social Anxiety Disorder: A Mega-Analysis Across Twelve Cohorts in the ENIGMA-Anxiety Working Group
Biological Psychiatry Cognitive Neuroscience and Neuroimaging2025
Eline F. Roelofs, Nynke A. Groenewold, Kinga Farkas, Alyssa H. Zhu, Si Gao, Tiana Borgers, Udo Dannlowski, Kira Flinkenflügel, Dominik Grotegerd, Tim Hahn, Andreas Jansen, Elisabeth J. Leehr, Tilo Kircher, Hannah Meinert, Igor Nenadić, Frederike Stein, Benjamín Straube, Tamer Demıralp, Raşit Tükel, P. Michiel Westenberg, Jochen Bauer, Anna Kraus, Alex Doruyter, Christine Löchner, David Hofmann, Thomas Straube, André Zugman, Monica E. Calkins, Raquel E. Gur, Ruben C Gur, Bart Larsen, Theodore D Sattertwaithe, Theresa Maria Slump, Roman A Vogler, Suzanne N. Avery, Jennifer Urbano Blackford, Jacqueline A. Clauss, Su Lui, Sophia I. Thomopoulos, Robert Vermeiren, Neda Jahanshad, Peter Kochunov, Paul M. Thompson, Daniel S. Pine, Dan J. Stein, Nic J.A. van der Wee, Janna Marie Bas‐Hoogendam
Abstract
Using a mega-analytic approach, several differences in WM microstructure were found between individuals with SAD and HC participants, both in the full sample and in age group-specific sensitivity analyses. Some neurobiological changes in WM tracts in individuals with SAD may vary with age and sex, whereas others may relate to broader transdiagnostic neurobiological features underlying psychopathology. Further research should investigate these issues in more detail.