Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

Citations Over TimeTop 1% of 2016 papers

Abstract

On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.

Related Papers

• → Estimating the size of the bacterial pan-genome(2009)357 cited
• → Differentiation and inter-genomic relationships among C, E and D genomes in the Oryzaofficinalis complex (Poaceae) as revealed by multicolor genomic in situ hybridization(2001)38 cited
• → Identification of signals required for the insertion of heterologous genome segments into the reovirus genome.(1995)23 cited
• → Genomic relationships of N-genome Triticum species(1992)17 cited
• → Sequencing of Chloroplast Genome in Sesame(2021)1 cited