Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer
Citations Over TimeTop 10% of 2016 papers
Abstract
Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. This population, marked by high levels of EpCAM and CD24, is also prevalent in human primary SCLC tumors. Murine SCLC TPCs are numerous and highly proliferative but not intrinsically chemoresistant, indicating that not all clinical features of SCLC are linked to TPCs. SCLC TPCs possess a distinct transcriptional profile compared to non-TPCs, including elevated MYC activity. Genetic and pharmacological inhibition of MYC in SCLC cells to non-TPC levels inhibits long-term propagation but not short-term growth. These studies identify a highly tumorigenic population of SCLC cells in mouse models, cell lines, and patient tumors and a means to target them in this most fatal form of lung cancer.
Related Papers
- → ALDH1+ stem cells demonstrate more stem cell-like characteristics than CD44+/CD24–/low stem cells in different molecular subtypes of breast cancer(2020)18 cited
- → Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice(2013)66 cited
- → Phenotypic characterization of mammosphere-forming cells from the human MA-11 breast carcinoma cell line(2010)31 cited
- → CD44+/CD24– Cancer Stem Cells Are Associated With Higher Grade of Canine Mammary Carcinomas(2015)17 cited
- Breast Cancer Stem Cell Involves Distant Metastasis Through Epithelial-Mesenchymal Transition Induced by Up-Regulating Twist Expression(2010)