Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling
Citations Over TimeTop 10% of 2016 papers
Abstract
Aberrant DNA methylation patterns in malignant cells allow insight into tumor evolution and development and can be used for disease classification. Here, we describe the genome-wide DNA methylation signatures of NPM-ALK-positive (ALK+) and NPM-ALK-negative (ALK-) anaplastic large-cell lymphoma (ALCL). We find that ALK+ and ALK- ALCL share common DNA methylation changes for genes involved in T cell differentiation and immune response, including TCR and CTLA-4, without an ALK-specific impact on tumor DNA methylation in gene promoters. Furthermore, we uncover a close relationship between global ALCL DNA methylation patterns and those in distinct thymic developmental stages and observe tumor-specific DNA hypomethylation in regulatory regions that are enriched for conserved transcription factor binding motifs such as AP1. Our results indicate similarity between ALCL tumor cells and thymic T cell subsets and a direct relationship between ALCL oncogenic signaling and DNA methylation through transcription factor induction and occupancy.
Related Papers
- → Global methylation profiles in DNA from different blood cell types(2011)132 cited
- → Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress(2018)15 cited
- → DNA methylation of stress-related genes and LINE-1 repetitive elements across the healthy human placenta(2012)36 cited
- Exploration on relationship of basic pathogenesis and disease symptom(2010)
- Discussion on pathogenesis levels of hypertension(2007)