A multicentre retrospective cohort study of ovarian germ cell tumours: Evidence for chemotherapy de-escalation and alignment of paediatric and adult practice
European Journal of Cancer2019Vol. 113, pp. 19–27
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Claire Newton, Krithika Murali, Amar Ahmad, Helen Hockings, Radha Graham, Viola Liberale, Shah‐Jalal Sarker, Jonathan A. Ledermann, Daniel M. Berney, Jonathan Shamash, Susana Banerjee, Sara Stoneham, Michelle Lockley
Abstract
Survival was excellent but chemotherapy toxicities were severe, implying significant overtreatment. Our data support the extension of reduced-toxicity, paediatric regimens to adults. Our practice-changing findings that IT was chemotherapy resistant and pathological grade uninformative strongly endorse exclusive surgical management of ovarian ITs at all ages.
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