Combining rare and common genetic variants improves population risk stratification for breast cancer
Genetics in Medicine Open2024Vol. 2, pp. 101826–101826
Citations Over TimeTop 10% of 2024 papers
Alexandre Bolze, Daniel Kiser, Kelly M. Schiabor Barrett, Gai Elhanan, Jamie M. Schnell Blitstein, Iva Neveux, Shaun Dabe, Harry Reed, Alexa R. Anderson, William J. Metcalf, Ekaterina Orlova, Ildiko Thibodeau, Natalie Telis, Ruomu Jiang, Nicole Washington, Matthew J. Ferber, Catherine Hajek, Elizabeth T. Cirulli, Joseph J. Grzymski
Abstract
Our findings suggest that a combined monogenic and polygenic approach allowed a better identification of participants with high risk while minimizing false positives.
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