Meta-analytic evidence for neuroimaging models of depression: State or trait?
Journal of Affective Disorders2013Vol. 151(2), pp. 423–431
Citations Over TimeTop 10% of 2013 papers
J.A. Graham, Gholamreza Salimi‐Khorshidi, Cindy C. Hagan, N. Walsh, Ian Goodyer, Belinda Lennox, John Suckling
Abstract
The focus of treatment effects in frontal areas indicates that dysregulation here may represent a biomarker of treatment response. Since the dysregulation in many subcortical regions in the case-control comparisons appeared insensitive to treatment, we propose that these act as trait vulnerability markers, or perhaps treatment insensitivity. Our findings allow these models of MDD to be applied to fMRI literature with some confidence.
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