Reversed-Phase High-Performance Liquid Chromatography Combined with On-Line UV Diode Array, FT Infrared, and 1H Nuclear Magnetic Resonance Spectroscopy and Time-of-Flight Mass Spectrometry: Application to a Mixture of Nonsteroidal Antiinflammatory Drugs
Analytical Chemistry2000Vol. 72(16), pp. 3922–3926
Citations Over TimeTop 10% of 2000 papers
Abstract
A prototype multiply hyphenated system has been applied to the analysis of a mixture of nonsteroidal antiinflammatory drugs separated by reversed-phase HPLC. Characterization of the model NSAIDs was achieved via a combination of diode array UV, 1H NMR, FT-IR spectroscopy, and time-of-flight mass spectrometry. This combination of spectrometers allowed the collection of UV, 1H NMR, IR, and mass spectra together with atomic composition data enabling almost complete structural characterization to be performed.
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