Fully Integrated On-Chip Electrochemical Detection for Capillary Electrophoresis in a Microfabricated Device
Citations Over TimeTop 1% of 2002 papers
Abstract
Microfabricated lab-on-a-chip devices employing a fully integrated electrochemical (EC) detection system have been developed and evaluated. Both capillary electrophoresis (CE) channels and all CE/EC electrodes were incorporated directly onto glass substrates via traditional microfabrication techniques, including photolithographic patterning, wet chemical etching, DC sputtering, and thermal wafer bonding. Unlike analogous CE/EC devices previously reported, no external electrodes were required, and critical electrode characteristics, including size, shape, and placement on the microchip, were established absolutely by the photolithography process. For the model analytes dopamine and catechol, detection limits in the 4-5 microM range (approximately 200 amol injected) were obtained with the Pt EC electrodes employed here, and devices gave stable analytical performance over months of usage.
Related Papers
- → Axial superresolution of two-photon microfabrication(2007)17 cited
- → Microfabrication of On-Demand Tapered Glass Capillaries by Etching Combined With Polishing(2022)6 cited
- → A Type of Two-Photon Microfabrication System and Experimentations(2011)1 cited
- Status and principle of two-photon microfabrication using femtosecond laser(2004)
- Progress of Two-Photon Three-Dimensional Microfabrication(2004)