Direct DNA Hybridization at Disposable Graphite Electrodes Modified with Carbon Nanotubes
Citations Over TimeTop 10% of 2006 papers
Abstract
The performance of glassy carbon (GCE) and graphite pencil electrodes (PGE) modified with multiwalled carbon nanotubes (CNTs) are compared, based on the direct electrochemical detection of nucleic acids. This is accomplished by monitoring the differential pulse voltammetry changes of the guanine signal. CNT-modified PGE compares favorably to that of the commonly used CNT-modified GCE owing to the intrinsic improved performance of the supporting PGE. The better intrinsic characteristics of the PGE are related to its composite structure and higher level of porosity compared to GCE. The performance characteristics of the direct DNA hybridization on the disposable CNT-modified PGE are studied in terms of optimum analytical conditions such as probe concentration, target concentration, hybridization time, and selectivity. The new DNA biosensor described here has shown some important advantages such being inexpensive, sensitive, selective, and able to generate reproducible results using a simple and direct electrochemical protocol.
Related Papers
- → Novel electrochemical sensor based on functionalized graphene for simultaneous determination of adenine and guanine in DNA(2010)251 cited
- → Electrochemical behavior of MOF-801/MWCNT-COOH/AuNPs: A highly selective electrochemical sensor for determination of guanine and adenine(2021)29 cited
- → Simultaneous determination of adenine and guanine in DNA based on carboxylic acid functionalized graphene(2010)9 cited
- → Investigation of electronic spectra on nucleic acid bases cations(1999)
- Novel electrochemical sensor based on functionalized graphene for simultaneous determination of adenine and guanine in DNA B Biointerfaces(2011)