Charge-Remote Fragmentation of Odd-Electron Peptide Ions

Citations Over TimeTop 10% of 2007 papers

Abstract

Comparison between the gas-phase fragmentation of odd-electron M+*, [M + H]2+*, and [M - 2H]-* ions of model peptides suggests that charge-remote radical-driven fragmentation pathways play an important role in the dissociation of odd-electron peptide ions. We have found that charge-remote processes are responsible for a variety of side-chain losses from the precursor ion and some backbone fragmentation. These fragmentation pathways most likely involve hydrogen abstraction by the radical site that initiates subsequent cleavages. These findings are generally relevant to our understanding of the fragmentation patterns of odd-electron peptide ions produced through various approaches including the capture of low-energy electrons, electron detachment, and electron transfer.

Related Papers

• → Activated-Electron Photodetachment Dissociation for the Structural Characterization of Protein Polyanions(2009)73 cited
• → Top-Down Characterization of Denatured Proteins and Native Protein Complexes Using Electron Capture Dissociation Implemented within a Modified Ion Mobility-Mass Spectrometer(2020)63 cited
• → Electron Capture Dissociation Mass Spectrometry in Characterization of Peptides and Proteins(2006)79 cited
• → Does Electron Capture Dissociation Cleave Protein Disulfide Bonds?(2012)48 cited
• → Spatial extent of fragment-ion abundances in electron transfer dissociation and electron capture dissociation mass spectrometry of peptides(2012)7 cited