Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry
Analytical Chemistry2012Vol. 84(11), pp. 4637–4646
Citations Over TimeTop 1% of 2012 papers
Abstract
This Feature will introduce the strategies of therapeutic antibodies (mAbs) in-depth characterization by mass spectrometry (MS) and discuss analytical comparison of biosimilar to originator mAbs, with the cases of trastuzumab and cetuximab. In addition, the structural and functional insights gained both by state-of-the art and emerging MS methods used for biobetters and next generation antibodies design and optimization will also be highlighted.
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