Airway Monitoring by Collection and Mass Spectrometric Analysis of Exhaled Particles
Citations Over TimeTop 10% of 2008 papers
Abstract
We describe a new method for simultaneously collecting particles in exhaled air for subsequent chemical analysis and measuring their size distribution. After forced exhalation, particles were counted and collected in spots on silicon wafers with a cascade impactor. Several phospholipids were identified by time-of-flight secondary ion mass spectrometric analysis of the collected spots, suggesting that the particles originated from the lower airways. The amount of particles collected in ten exhalations was sufficient for characterizing the phospholipid composition. The feasibility of the technique in respiratory research is demonstrated by analysis of the phospholipid composition of exhaled particles from healthy controls, patients with asthma, and patients with cystic fibrosis. We believe this technology will be useful for monitoring patients with respiratory disease and has a high potential to detect new biomarkers in exhaled air.
Related Papers
- → The lung cancer breath signature: a comparative analysis of exhaled breath and air sampled from inside the lungs(2015)103 cited
- → Increased carbon monoxide in exhaled air of patients with seasonal allergic rhinitis(1999)57 cited
- → Electronic nose for analysis of volatile organic compounds in air and exhaled breath.(2017)1 cited
- → Applying a data acquisition system to the analysis of breath alcohol profiles(1989)