Detection of Volatile Organic Compounds in Breath Using Thermal Desorption Electrospray Ionization-Ion Mobility-Mass Spectrometry
Citations Over TimeTop 10% of 2010 papers
Abstract
A thermal desorption unit has been interfaced to an electrospray ionization-ion mobility-time-of-flight mass spectrometer. The interface was evaluated using a mixture of six model volatile organic compounds which showed detection limits of <1 ng sample loaded onto a thermal desorption tube packed with Tenax, equivalent to sampled concentrations of 4 microg L(-1). Thermal desorption profiles were observed for all of the compounds, and ion mobility-mass spectrometry separations were used to resolve the probe compound responses from each other. The combination of temperature programmed thermal desorption and ion mobility improved the response of selected species against background ions. Analysis of breath samples resulted in the identification of breath metabolites, based on ion mobility and accurate mass measurement using siloxane peaks identified during the analysis as internal lockmasses.
Related Papers
- → Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry(2006)124 cited
- → Detection and Characterization of Natural Polyamines by High-Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization (Electrospray Ionization) Mass Spectrometry(2002)23 cited
- → Desorption Electrospray Ionization Mass Spectrometry(2010)4 cited
- Studies of Heterogeneous/Homogeneous Ion-Molecule Reactions by Ambient Ionization Mass Spectrometry(2011)