Thin-Film Microbiosensors for Glucose−Lactate Monitoring
Analytical Chemistry1996Vol. 68(18), pp. 3173–3179
Citations Over TimeTop 10% of 1996 papers
G. Jobst, Isabella Moser, M. Varahram, P. Svasek, E. Aschauer, Zlatko Trajanoski, Paul Wach, Peter Kotanko, F. Skrabal, G. Urban
Abstract
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means of photopatterning of enzyme-containing photosensitive membrane precursors. This device shows no cross-talk and a lifetime for both the glucose and the lactate sensors of more than 2 weeks when continuously operated in undiluted bovine serum. Linear response ranges of up to 40 mM for glucose and 25 mM for L-lactate, in combination with 95% response times of 0.98 with respect to laboratory techniques. Subcutaneous measurements of glucose levels in pigs were close to the corresponding blood levels obtained without in vivo calibration.
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