DNA Biosensor for the Detection of Hydrazines
Analytical Chemistry1996Vol. 68(13), pp. 2251–2254
Citations Over TimeTop 10% of 1996 papers
Joseph Wang, Manuel Chicharro, Gustavo A. Rivas, Xiaohua Cai, Narasaiah Dontha, Pércio A. M. Farias, Haruki Shiraishi
Abstract
A double-stranded (ds) DNA-coated carbon paste electrode is employed as a remarkably sensitive biosensor for the detection of hydrazine compounds. The sensor relies on monitoring changes in the intrinsic anodic response of the surface-confined DNA resulting from its interaction with hydrazine compounds and requires no label or indicator. Short reaction times (1-10 min) are sufficient for monitoring part-per-billion levels of different hydrazines. Applicability to untreated natural water samples is illustrated. The response mechanism is discussed, along with prospects of using DNA biosensors for quantitaing other important molecules and elucidating DNA interactions and damage.
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