Characterization of an Inkjet Chemical Microdispenser for Combinatorial Library Synthesis
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Abstract
Solenoid inkjet valves are characterized and implemented in an automated chemical microdispenser, the ChemJet, to be used for combinatorial library synthesis. A novel high-density format for chemical synthesis and assay is also presented. The “ChemSheet” consists of a 48 × 48 array of 8-μL wells, molded as an 8 1/2-in. × 11-in. sheet of polypropylene. The development of the ChemSheet created the need for high-speed, parallel microdispensing. The ChemJet addresses this need by providing the ability to dispense 8-μL volumes of chemical reagents to the 2304 wells of the ChemSheet in under 10 s, with an average reproducibility of ∼2.2%. Results from both quantitative and qualitative characterization of inkjet solenoid valves are presented. Characterization of the ChemJet instrument is also presented.
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