N-Alkylation of Amines with Alcohols Catalyzed by Manganese(II) Chloride or Bromopentacarbonylmanganese(I)
The Journal of Organic Chemistry2021Vol. 86(3), pp. 2254–2263
Citations Over TimeTop 10% of 2021 papers
Abstract
A manganese-catalyzed N-alkylation reaction of amines with alcohols via hydrogen autotransfer strategy has been demonstrated. The developed practical catalytic system including an inexpensive, nontoxic, commercially available MnCl2 or MnBr(CO)5 as the metal salt and triphenylphosphine as a ligand provides access to diverse aromatic, heteroaromatic, and aliphatic secondary amines in moderate-to-high yields. In addition, this operationally simple protocol is scalable to the gram level and suitable for synthesizing heterocycles such as indole and resveratrol-derived amines known to be active for Alzheimer's disease.
Related Papers
- → Study on manganese volatilization behavior of Fe–Mn–C–Al twinning-induced plasticity steel(2021)23 cited
- Effects of Manganese Availability on Acquisition and Distribution of Manganese,Iron and Phosphorus in Soybean [Glycine max (L.) Merr.](2010)
- → Studies in soil and plant manganese(1962)13 cited
- → The relative content of manganese in plants(1957)9 cited
- → ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ(2024)