Benzylic Phosphates in Friedel–Crafts Reactions with Activated and Unactivated Arenes: Access to Polyarylated Alkanes
The Journal of Organic Chemistry2016Vol. 81(5), pp. 2135–2142
Citations Over TimeTop 10% of 2016 papers
Abstract
Easily reachable electron-poor/rich primary and secondary benzylic phosphates are suitably used as substrates for Friedel-Crafts benzylation reactions with only 1.2 equiv activated/deactivated arenes (no additional solvent) to access structurally and electronically diverse polyarylated alkanes with excellent yields and selectivities at room temperature. Specifically, diversely substituted di/triarylmethanes are generated within 2-30 min using this approach. A wide number of electron-poor polyarylated alkanes are easily accomplished through this route by just tuning the phosphates.
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