An Injectable and Instant Self-Healing Medical Adhesive for Wound Sealing
Citations Over TimeTop 1% of 2020 papers
Abstract
Designing versatile functional medical adhesives with injectability, self-healing, and strong adhesion is of great significance to achieve desirable therapeutic effects for promoting wound sealing in healthcare. Herein, a self-healing injectable adhesive is fabricated by physical interaction of polyphenol compound tannic acid (TA) and eight-arm poly(ethylene glycol) end-capped with succinimide glutarate active ester (PEG-SG). The hydrogen bonding induced from the structural unit (-CH2-CH2-O-) of PEG and catechol hydroxyl (-OH) of TA, accompanied by ester exchange between N-hydroxysuccinimide (-NHS) and amino (-NH2) of proteins, contributes to self-healing ability and rapid strong adhesion. Notably, the PEG/TA adhesive can repeatedly adhere to rigid porcine tissues, close the coronary artery under a large incision tension, and bear a heavy load of 2 kg. By exhibiting shear-thinning and anti-swelling properties, the PEG/TA adhesive can be easily applied through single-syringe extrusion onto various wounds. The single-channel toothpaste-like feature of the adhesive ensures its storage hermetically for portable usage. Moreover, in vivo operation and histological H&E staining results indicate that the PEG/TA adhesive greatly accelerates wound healing and tissue regeneration in a rat model. With the specialty of injectability, instant self-healing, and long-lasting strong adhesion to facilitate excellent therapeutic effects, the multifunctional PEG/TA adhesive may provide a new alternative for self-rescue and surgical situations.
Related Papers
- → Development of anti-microbial jute fabrics via in situ formation of cellulose–tannic acid–metal ion complex(2009)56 cited
- → Tannic Acid as a Natural Ferroptosis Inhibitor: Mechanisms and Beneficial Role of 3’‐ O ‐Galloylation(2021)10 cited
- → Effective Lac Dyeing of Cotton Fabric by Pretreating with Tannic Acid and Aluminum Acetate(2010)6 cited
- → Behaviour of tannic acid from various commercial sources towards redox, metal complexing and protein precipitation assays of tannins(1993)43 cited
- → Sb2O3 prices raised four times in twelve months(2002)