Janus Silver/Silica Nanoplatforms for Light-Activated Liver Cancer Chemo/Photothermal Therapy
Citations Over TimeTop 10% of 2017 papers
Abstract
Stimuli-triggered nanoplatforms have become attractive candidates for combined strategies for advanced liver cancer treatment. In this study, we designed a light-responsive nanoplatform with folic acid-targeting properties to surmount the poor aqueous stability and photostability of indocyanine green (ICG). In this Janus nanostructure, ICG was released on-demand from mesoporous silica compartments in response to near-infrared (NIR) irradiation, exhibiting predominant properties to convert light to heat in the cytoplasm to kill liver cancer cells. Importantly, the silver ions released from the silver compartment that were triggered by light could induce efficient chemotherapy to supplement photothermal therapy. Under NIR irradiation, ICG-loaded Janus nanoplatforms exhibited synergistic therapeutic capabilities both in vitro and in vivo compared with free ICG and ICG-loaded mesoporous silica nanoparticles themselves. Hence, our Janus nanoplatform could integrate ICG-based photothermal therapy and silver ion-based chemotherapy in a cascade manner, which might provide an efficient and safe strategy for combined liver cancer therapy.
Related Papers
- → Indocyanine green derived carbon dots with significantly enhanced properties for efficient photothermal therapy(2022)76 cited
- → Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma(2014)77 cited
- → Indocyanine Green(1984)82 cited
- → Tumor Therapy: NIR Light Propulsive Janus‐like Nanohybrids for Enhanced Photothermal Tumor Therapy (Small 39/2016)(2016)3 cited
- Traditional Specialties at the Turn of the 21st Century: A Janus View: A Janus View(2001)