Multifunctional Bi@PPy-PEG Core–Shell Nanohybrids for Dual-Modal Imaging and Photothermal Therapy

Citations Over TimeTop 10% of 2017 papers

Abstract

High-performance theranostic nanoagents, which integrate multimodal imaging and photothermal therapy for clinical anticancer treatment, are highly desired. Herein, we report the synthesis and bioapplication of a multifunctional theranostic nanoagent based on polyethylene glycol (PEG)-modified polypyrrole (PPy)-coated bismuth (Bi) nanohybrids (referred to as Bi@PPy-PEG NHs) for X-ray computed tomography/photoacoustic (CT/PA) dual-modal imaging and photothermal therapy (PTT). The obtained Bi@PPy-PEG NHs have a distinct core-shell structure with the metallic Bi nanoparticle as the inner core and the PPy-PEG layer as the shell. The Bi@PPy-PEG NHs show excellent physiological stability and compatibility, without noticeable cytotoxicity. Importantly, the NHs exhibit strong NIR absorbance and remarkable photothermal conversion capability and conversion stability, with the photothermal conversion efficiency as high as ∼46.3%. Thanks to the strong PTT effect, highly effective photothermal ablation on cancer cells has been achieved both in vitro and in vivo. Furthermore, a high-contrast in vitro and in vivo CT/PA dual-modal imaging has been realized, showing great potential to provide comprehensive diagnosis information for antitumor treatment. In particular, the CT enhancement efficiency of the NHs is of ∼14.4 HU mM-1, which is ∼3.7-fold that of clinically used iohexol. Therefore, our work highlights the potential of using such core-shell Bi@PPy-PEG NHs as a versatile theranostic nanoplatform for cancer imaging and therapy.

Related Papers

• → Selectivity of protein precipitation with polyethylene glycol fractions of various molecular weights(1976)81 cited
• → ULTRASOUND PROMOTED ONE POT SYNTHESIS OF 1,5-BENZOTHIAZEPINES USING POLYETHYLENE GLYCOL (PEG-400)(2018)10 cited
• → The polyethylene glycol (PEG) positive effect in protein crystallization(1996)1 cited
• → Separation and purification of papain from papaya latex using aqueous two-phase extraction.(1989)5 cited
• Effects of Polyethylene Glycol(PEG)-simulated Drought Stress on Mulberry Seed Germination and Physiology(2006)