Rhodium-Catalyzed Intermolecular Stereoselective Allylation of Indoles with Allenes
ACS Catalysis2022Vol. 12(16), pp. 10141–10146
Citations Over TimeTop 15% of 2022 papers
Abstract
A rhodium-catalyzed C–H functionalization-based intermolecular allylation of indoles with trisubstituted allenes has been developed. This synthetic process proceeds with an excellent regioselectivity, Z-selectivity, high efficiency of chirality transfer, and a wide tolerance of reactive functional groups under mild conditions. Late-stage modification on a series of complex bioactive or drug molecules and various synthetic transformations has been demonstrated. A reaction mechanism has been proposed on the basis of mechanistic experiments and SAESI-MS studies.
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