Iron(III)-Light-Induced Homolysis: A Dual Photocatalytic Approach for the Hydroacylation of Alkenes Using Acyl Radicals via Direct HAT from Aldehydes
ACS Catalysis2022Vol. 12(21), pp. 13549–13554
Citations Over TimeTop 10% of 2022 papers
Abstract
A dual photocatalytic protocol was developed to generate acyl radicals from readily available aldehydes via hydrogen atom transfer (HAT). Synergistic cooperation, being supported by DFT studies, between earth-abundant iron(III)chloride and 9,10-diphenylanthracene (DPA) to activate the aldehyde for a HAT step proved to be an efficient, economic, and green route for the hydroacylation of electron-deficient alkenes under UV-light irradiation with broad functional group compatibility. This methodology can be conveniently scaled up and applied to produce valuable materials from renewable feedstock chemicals.
Related Papers
- → Isolation of a stable acylrhodium(III) hydride intermediate formed during aldehyde decarbonylation. Hydroacylation(1978)191 cited
- → A redox-neutral synthesis of ketones by coupling of alkenes and amides(2019)37 cited
- → Rhodium(I)‐Catalyzed Hydroacylation(2019)12 cited
- → ChemInform Abstract: Facile and Chemoselective Rhodium‐Catalyzed Intramolecular Hydroacylation of α,α‐Disubstituted 4‐Alkylidenecyclopropanals.(2012)
- → ChemInform Abstract: ISOLATION OF A STABLE ACYLRHODIUM(III) HYDRIDE INTERMEDIATE FORMED DURING ALDEHYDE DECARBONYLATION. HYDROACYLATION(1978)