Stereoselective 1,6-Conjugate Addition/Annulation of para-Quinone Methides with Vinyl Epoxides/Cyclopropanes
ACS Catalysis2016Vol. 6(10), pp. 6408–6412
Citations Over TimeTop 1% of 2016 papers
Abstract
Here, we present an unprecedented formal [3 + 2] cycloaddition of para-quinone methides with vinyl epoxides/cyclopropanes to deliver a wide range of spiro[4.5]decanes in high efficiency and stereoselectivity. The commercial availability of the catalysts and reagents, together with the convenient procedure, makes it an attractive method in asymmetric synthesis.
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