Dual-Functional Chiral Cu-Catalyst-Induced Photoredox Asymmetric Cyanofluoroalkylation of Alkenes

Citations Over TimeTop 10% of 2019 papers

Abstract

In the past decades, the Cu-catalyzed asymmetric organic reactions have been well-developed. By contrast, the potential of Cu to serve as a chiral photocatalyst remains underexplored. We here report the visible-light-induced, Cu-catalyzed photoredox enantioselective cyanofluoroalkylation of alkenes. In the reaction, the Cu-based single catalyst played a dual role, as both the photoredox catalyst for the outer-sphere electron transfer and the asymmetric cross-coupling catalyst for enantioselective C–CN bond formation.

Related Papers

• → Recent developments in enantioselective iron-catalyzed transformations(2019)58 cited
• → Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers(2010)37 cited
• → Methods of Asymmetric Synthesis—Enantioselective Catalytic Hydrogenation(1971)142 cited
• → The First Catalytic Enantioselective Synthesis of (R)-(+) Lasiodiplodin(1993)18 cited
• → Chiral B(III) Lewis Acids(2000)19 cited