Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes
ACS Catalysis2019Vol. 9(6), pp. 5726–5731
Citations Over TimeTop 10% of 2019 papers
Abstract
A copper-catalyzed borylfluoromethylation of alkenes with fluoromethyl iodide and diboron reagents was disclosed. This protocol afforded the previously unknown and synthetically useful borylfluoromethylated alkanes in good yields and excellent regioselectivity. Its synthetic application was illustrated through the derivatization of organoboron products and preparation of monofluorinated ibuprofen.
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