Design and Application of a DNA-Encoded Macrocyclic Peptide Library
ACS Chemical Biology2017Vol. 13(1), pp. 53–59
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Zhengrong Zhu, Alex Shaginian, LaShadric C. Grady, Thomas O’Keeffe, Xiangguo Shi, Christopher P. Davie, Graham L. Simpson, Jeffrey A. Messer, Ghotas Evindar, Robert N. Bream, Praew Thansandote, Naomi R. Prentice, Andrew M. Mason, Sandeep Pal
Abstract
A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.
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