Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
Citations Over TimeTop 1% of 2019 papers
Abstract
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (1O2) generation efficiency and large two-photon absorption (2PA) cross-sections are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that the polymerization of small-molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency, and large 2PA cross-sections. A pair of conjugated polymer PSs were designed and synthesized, and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
Related Papers
- → The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy(2018)154 cited
- → Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling(2010)135 cited
- → In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy(2008)39 cited
- → Design of novel photosensitizers and controlled singlet oxygen generation for photodynamic therapy(2021)11 cited
- → Photodynamic Therapy: Controllable Photodynamic Therapy Implemented by Regulating Singlet Oxygen Efficiency (Adv. Sci. 7/2017)(2017)3 cited