A Facile Synthesis, In vitro and In vivo MR Studies of d-Glucuronic Acid-Coated Ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent
ACS Applied Materials & Interfaces2011Vol. 3(9), pp. 3325–3334
Citations Over TimeTop 10% of 2011 papers
Krishna Kattel, Ja Young Park, Wenlong Xu, Han Gyeol Kim, Eun Jung Lee, Badrul Alam Bony, Woo Choul Heo, Jae Jun Lee, Seong-Uk Jin, Jong Su Baeck, Yongmin Chang, T. J. Kim, Jı Eun Bae, Kwon Seok Chae, Gang Ho Lee
Abstract
A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln(2)O(3) (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy(2)O(3) nanoparticle because it showed the highest r(2) relaxivity among studied nanoparticles. Its performance as a T(2) MRI contrast agent was for the first time proved in vivo through its 3 T T(2) MR images of a mouse, showing that it can be further exploited for the rational design of a new T(2) MRI contrast agent at high MR fields.
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