Preparation of Imprinted Polymers at Surface of Magnetic Nanoparticles for the Selective Extraction of Tadalafil from Medicines
Citations Over TimeTop 10% of 2011 papers
Abstract
In this paper, highly selective core-shell molecularly imprinted polymers (MIPs) of tadalafil on the surface of magnetic nanoparticles (MNPs) were prepared. Three widely used functional monomers 2-(trifluoromethyl) acrylic acid (TFMAA), acrylic acid (AA), and methacrylic acid (MAA) were compared theoretically as the candidates for MIP preparation. MIP-coated magnetic nanoparticles (MIP-coated MNPs) showed large adsorption capacity, high recognition ability, and fast binding kinetics for tadalafil. Furthermore, because of the good magnetic properties, MIP-coated MNPs can achieve rapid and efficient separation with an external magnetic field simply. The resulting MIP-coated MNPs were used as dispersive solid-phase extraction (DSPE) materials coupled with HPLC-UV for the selective extraction and detection of tadalafil from medicines (herbal sexual health products). Encouraging results were obtained. The amounts of tadalafil that were detected from the herbal sexual health product was 43.46 nmol g(-1), and the recoveries were in the range of 87.36-90.93% with the RSD < 6.55%.
Related Papers
- → Molecularly Imprinted Polymers for Solid Phase Extraction(2006)206 cited
- → Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs(2007)87 cited
- → The Characteristic and Application of Molecularly Imprinted Polymer: Efficient Sample Preconcentration of Antibiotic Cefathiamidine from Human Plasma and Serum by Solid Phase Extraction(2005)17 cited
- → Acrylic (and Methacrylic) Acid Polymers(2002)25 cited
- Selective solid-phase extraction of phenylcarbamic acid derivatives from a rat serum by molecularly imprinted polymer(2008)