Permission to Enter Cell by Shape: Nanodisk vs Nanosphere
ACS Applied Materials & Interfaces2012Vol. 4(8), pp. 4099–4105
Citations Over TimeTop 10% of 2012 papers
Yi Zhang, Samuel Tekobo, Ying Tu, Qunfang Zhou, Xinlong Jin, Sergey A. Dergunov, Eugene Pinkhassik, Bing Yan
Abstract
Changing polystyrene nanoparticles from three-dimensional spherical shape to two-dimensional disk shape promotes their cell surface binding with significant reduction of cell uptake. As a result of lower cell uptake, nanodisks show very little perturbations on cell functions such as cellular ROS generation, apoptosis and cell cycle progression compared to nanospheres. Therefore, disk-shaped nanoparticles may be a promising template for developing cell membrane-specific and safer imaging agents for a range of biomedical applications such as molecular imaging, tissue engineering, cell tracking, and stem cell separation.
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