Enhanced Bioactivity of Mg–Nd–Zn–Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application
Citations Over TimeTop 10% of 2015 papers
Abstract
Magnesium (Mg) alloys have revolutionized the application of temporary load-bearing implants as they meet both engineering and medical requirements. However, rapid degradation of Mg alloys under physiological conditions remains the major obstacle hindering the wider use of Mg-based implants. Here we developed a simple method of preparing a nanoscale MgF2 film on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to reduce the corrosion rate as well as improve the biological response. The corrosion rate of JDBM alloy exposed to artificial plasma is reduced by ∼20% from 0.337 ± 0.021 to 0.269 ± 0.043 mm·y(-1) due to the protective effect of the MgF2 film with a uniform and dense physical structure. The in vitro cytocompatibility test of MgF2-coated JDBM using human umbilical vein endothelial cells indicates enhanced viability, growth, and proliferation as compared to the naked substrate, and the MgF2 film with a nanoscale flakelike feature of ∼200-300 nm presents a much more favorable environment for endothelial cell adhesion, proliferation, and alignment. Furthermore, the animal experiment via implantation of MgF2-coated JDBM stent to rabbit abdominal aorta confirms excellent tissue compatibility of the well re-endothelialized stent with no sign of thrombogenesis and restenosis in the stented vessel.
Related Papers
- The damage on human umbilical vein endothelial cell lines induced by trichlorfon(2008)
- Salt spray corrosion resistance of iron-based alloy 30Cr2Ni4MoV(2013)
- The Molecular Mechanism of the Proliferation of Human Umbilical Vein Endothelial Cells Induced by Angiolensin II(2005)
- Salt spray corrosion resistance of the iron-based alloy 1Cr12Ni3MoVN(2013)
- Iron alloys outdoor corrosion and laboratory simulation -comparison(2017)