Temperature-Sensitive Fluorescent Organic Nanoparticles with Aggregation-Induced Emission for Long-Term Cellular Tracing
ACS Applied Materials & Interfaces2015Vol. 7(5), pp. 3420–3425
Citations Over TimeTop 10% of 2015 papers
Zhen Wang, Tuying Yong, Jiangshan Wan, Zihe Li, Hao Zhao, Yanbing Zhao, Lu Gan, Xiangliang Yang, Huibi Xu, Chun Zhang
Abstract
Temperature-sensitive organic nanoparticles with AIE effect were assembled in water from tetraphenylethene-based poly(N-isopropylacrylamide) (TPE-PNIPAM), which was synthesized by ATRP using TPE derivative as initiator. The size and fluorescence of TPE-PNIPAM nanoparticles can be tuned by varying the temperature. These nanoparticles can be internalized readily by HeLa cells and can be used as long-term tracer in live cells to be retained for as long as seven passages.
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