Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog
Accounts of Chemical Research2000Vol. 33(12), pp. 879–888
Citations Over TimeTop 1% of 2000 papers
Abstract
In 1893, P. Biginelli reported the synthesis of functionalized 3, 4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea, and ethyl acetoacetate. In the past decade, this long-neglected multicomponent reaction has experienced a remarkable revival, mainly due to the interesting pharmacological properties associated with this dihydropyrimidine scaffold. In this Account, we highlight recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
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